Non-invasive brain stimulation through olfactory pathway to reduce neurocognitive dysfunction - Translational Brain Function & Neuromodulation Lab
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Non-invasive brain stimulation through olfactory pathway to reduce neurocognitive dysfunction
Date: 2018-present
Overview
In nasal breathing, the airflow activates mechanosensitive olfactory sensory neurons (OSNs) of the nasal epithelium and entrains oscillatory neural activity in the olfactory bulb (OB). Besides processing odorant information, OSNs also respond to mechanical stimulation of airflow passage. Rhythmic OB activation by nasal breathing generates respiration-coupled oscillations propagating throughout the cortical and subcortical regions implicated in cognitive functions such as learning and memory. Interestingly, nasal breathing diversion to the oral root as well as OB inhibition or OSN ablation abolishes these respiration-entrained brain rhythms, which are subsequently associated with cognitive impairments.
Therefore, it seems that electrical and mechanical stimulation of OSNs, as a non-invasive brain stimulation method, can improve neural homeostasis to prevent disease progression or treat neuro-cognitive dysfunction. This project focuses on learning and memory disorders, Alzheimer's disease, cognitive impairment following mechanical ventilation, depression and anxiety.
Techniques used in animals include electrophysiological recording (multi-electrode recording of local field potentials (LFP) in conscious animals during behavioral experiments, spike recording and patch clamp recording), brain imaging (MRI), invasive and non-invasive brain stimulation, brain molecular and histological examination. Also, human and clinical techniques include electroencephalography (EEG), brain imaging (MRI and fMRI) and non-invasive brain stimulation. Data analysis is performed with an emphasis on electrical signal processing and image processing.
Selected articles
Salimi M, Nazari M, Shahsavar P, Dehghan S, Javan M, Mirnajafi-Zadeh J, Raoufy MR. Olfactory bulb stimulation mitigates Alzheimer's-like disease progression. CNS Neurosci Ther. 2024 Oct;30(10):e70056. doi: 10.1111/cns.70056.
Zeynali F, Raoufy MR, Gharakhanlou R. Investigating Olfactory Sensory Neurons Facilitation For Aerobic Exercise-induced Spatial Memory Improvement. Basic Clin Neurosci. 2024 May-Jun;15(3):355-366. doi: 10.32598/bcn.2022.4029.1.
Farkhondeh Tale Navi F, Heysieattalab S, Raoufy MR, Sabaghypour S, Nazari M, Nazari MA. Adaptive closed-loop modulation of cortical theta oscillations: Insights into the neural dynamics of navigational decision-making. Brain Stimul. 2024 Sep 12;17(5):1101-1118. doi: 10.1016/j.brs.2024.09.005.
Mooziri M, Samii Moghaddam A, Mirshekar MA, Raoufy MR. Olfactory bulb-medial prefrontal cortex theta synchronization is associated with anxiety. Sci Rep. 2024 May 27;14(1):12101. doi: 10.1038/s41598-024-63101-z.
Riazi H, Nazari M, Raoufy MR, Mirnajafi-Zadeh J, Shojaei A. Olfactory Epithelium Stimulation Using Rhythmic Nasal Air-Puffs Improves the Cognitive Performance of Individuals with Acute Sleep Deprivation. Brain Sci. 2024 Apr 13;14(4):378. doi: 10.3390/brainsci14040378.
Shahsavar P, Ghazvineh S, Raoufy MR. From nasal respiration to brain dynamic. Rev Neurosci. 2024 Apr 5;35(6):639-650. doi: 10.1515/revneuro-2023-0152.
Ghazvineh S, Salimi M, Dehghan S, Asemi-Rad A, Dehdar K, Salimi A, Jamaati H, Raoufy MR. Stimulating olfactory epithelium mitigates mechanical ventilation-induced hippocampal inflammation and apoptosis. Hippocampus. 2023 Mar 2. doi: 10.1002/hipo.23523.
Khodadadi M, Zare M, Rezaei M, Bakhtiarzadeh F, Barkley V, Shojaei A, Raoufy MR, Mirnajafi-Zadeh J. Effect of low frequency stimulation of olfactory bulb on seizure severity, learning, and memory in kindled rats. Epilepsy Res. 2022 Dec;188:107055. doi: 10.1016/j.eplepsyres.2022.107055.
Salimi M, Ayene F, Parsazadegan T, Nazari M, Jamali Y, Raoufy MR. Nasal airflow promotes default mode network activity. Respir Physiol Neurobiol. 2023 Jan;307:103981. doi: 10.1016/j.resp.2022.103981.
Salimi M, Tabasi F, Nazari M, Ghazvineh S, Raoufy MR. The olfactory bulb coordinates the ventral hippocampus-medial prefrontal cortex circuit during spatial working memory performance. J Physiol Sci. 2022 Apr 25;72(1):9. doi: 10.1186/s12576-022-00833-5.
Salimi M, Tabasi F, Abdolsamadi M, Dehghan S, Dehdar K, Nazari M, Javan M, Mirnajafi-Zadeh J, Raoufy MR. Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer's disease model. Sci Rep. 2022 Mar 15;12(1):4394. doi: 10.1038/s41598-022-08528-y.
Salimi M, Javadi AH, Nazari M, Bamdad S, Tabasi F, Parsazadegan T, Ayene F, Karimian M, Gholami-Mahtaj L, Shadnia S, Jamaati H, Salimi A, Raoufy MR. Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach. Neuromodulation. 2022 Dec;25(8):1351-1363. doi: 10.1016/j.neurom.2021.11.003.
Salimi M, Tabasi F, Ghazvineh S, Jamaati H, Salimi A, Raoufy MR. Stimulating Neural Pathways to Reduce Mechanical Ventilation-associated Neurocognitive Dysfunction. Am J Respir Crit Care Med. 2022 Mar 1;205(5):588-589. doi: 10.1164/rccm.202110-2419LE.
Salimi M, Tabasi F, Nazari M, Ghazvineh S, Salimi A, Jamaati H, Raoufy MR. The olfactory bulb modulates entorhinal cortex oscillations during spatial working memory. J Physiol Sci. 2021 Jun 30;71(1):21. doi: 10.1186/s12576-021-00805-1.
Ghazvineh S, Salimi M, Nazari M, Garousi M, Tabasi F, Dehdar K, Salimi A, Jamaati H, Mirnajafi-Zadeh J, Arabzadeh E, Raoufy MR. Rhythmic air-puff into nasal cavity modulates activity across multiple brain areas: A non-invasive brain stimulation method to reduce ventilator-induced memory impairment. Respir Physiol Neurobiol. 2021 May;287:103627. doi: 10.1016/j.resp.2021.103627.
Salimi M, Ghazvineh S, Zare M, Parsazadegan T, Dehdar K, Nazari M, Mirnajafi-Zadeh J, Jamaati H, Raoufy MR. Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis. PLoS One. 2019 Sep 11;14(9):e0221978. doi: 10.1371/journal.pone.0221978.
Jand Y, Raoufy MR, Dehpour AR. Brain wave disturbance and cognitive impairment after CPR. Med Hypotheses. 2019 May;126:129-130. doi: 10.1016/j.mehy.2019.03.009.
Parsazadegan T, Salimi M, Ghazvineh S, Raoufy MR. Cognitive disorders in allergic rhinitis may be induced by decline of respiration entrained rhythm in the brain. Med Hypotheses. 2018 Dec;121:89-90. doi: 10.1016/j.mehy.2018.09.037.
Tabasi F, Raoufy MR. Eliminated respiration-coupled oscillations in the brain as a possible link between adenotonsillar hypertrophy and cognitive impairment. Med Hypotheses. 2018 Mar;112:63-64.