Complex systems in medicine - Translational Brain Function & Neuromodulation Lab
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Complex systems in medicine
Date: 2012-2017
Overview
Physiological mechanisms underlying cardio-respiratory variations include “deterministic” multiple feedback loops regulating the cardio-respiratory system, as well as “stochastic” processes at the cellular and molecular levels (e.g. ion channels, neurotransmitter release etc). The stochastic nature of real systems precludes the use of deterministic models to describe physiological variations. Thus, stochastic methods may provide useful information on the complexity of physiological rhythms, and uncover mechanisms which are associated with complex pathologies such as cardiac arrhythmia and asthma.
Selected articles
Eslami-Behroozi M, Shahsavar P, Vali R, Raoufy MR. Breathing pattern alteration from weanling to old age in male Sprague-Dawley rats. Respir Physiol Neurobiol. 2024 Oct 1;331:104357. doi: 10.1016/j.resp.2024.104357.
Enayati P, Dehdar K, Javan M, Raoufy MR. The protective effect of inhaled corticosteroid on lung inflammation and breathing pattern complexity in a rat model of asthma. Respir Physiol Neurobiol. 2023 May 12;314:104072. doi: 10.1016/j.resp.2023.
Enayat J, Mahdaviani SA, Rekabi M, Ghaini M, Eslamian G, Fallahi M, Ghazvineh S, Sharifinejad N, Raoufy MR, Velayati AA. Respiratory pattern complexity in newly-diagnosed asthmatic patients. Respir Physiol Neurobiol. 2022 Jun;300:103873. doi: 10.1016/j.resp.2022.103873.
Satti R, Abid NU, Bottaro M, De Rui M, Garrido M, Raoufy MR, Montagnese S, Mani AR. The Application of the Extended Poincaré Plot in the Analysis of Physiological Variabilities. Front Physiol. 2019 Feb 19;10:116. doi: 10.3389/fphys.2019.00116.
Taghizadeh N, Eslaminejad A, Raoufy MR. Protective effect of heart rate variability biofeedback on stress-induced lung function impairment in asthma. Respir Physiol Neurobiol. 2019 Apr;262:49-56. doi: 10.1016/j.resp.2019.01.011.
Nataj A, Eftekhari G, Raoufy MR, Mani AR. The effect of fractal-like mechanical ventilation on vital signs in a rat model of acute-on-chronic liver failure. Physiol Meas. 2018 Nov 26;39(11):114008. doi: 10.1088/1361-6579/aaea10.
Ilka F, Javan M, Raoufy MR. Variable ventilation decreases airway responsiveness and improves ventilation efficiency in a rat model of asthma. Respir Physiol Neurobiol. 2018 Sep;255:39-42. doi: 10.1016/j.resp.2018.05.007.
Pazhoohan S, Raoufy MR, Javan M, Hajizadeh S. Effect of Rho-kinase inhibition on complexity of breathing pattern in a guinea pig model of asthma. PLoS One. 2017 Oct 31;12(10):e0187249. doi: 10.1371/journal.pone.0187249.
Eslami-Behroozi M, Javan M, Raoufy MR. Effect of airway remodeling and hyperresponsiveness on complexity of breathing pattern in rat. Respir Physiol Neurobiol. 2018 Jan;247:65-70. doi: 10.1016/j.resp.2017.09.007.
Raoufy MR, Ghafari T, Mani AR. Complexity Analysis of Respiratory Dynamics. Am J Respir Crit Care Med. 2017 Jul 15;196(2):247-248. doi: 10.1164/rccm.201701-0026LE.
Eslami-Behroozi M, Pazhoohan S, Aref E, Zare L, Javan M, Hajizadeh S, Raoufy MR. Bronchoconstriction Induces Structural and Functional Airway Alterations in Non-sensitized Rats. Lung. 2017 Apr;195(2):167-171. doi: 10.1007/s00408-016-9970-4.
Jamaati H, Nazari M, Darooei R, Ghafari T, Raoufy MR. Role of shear stress in ventilator-induced lung injury. Lancet Respir Med. 2016 Aug;4(8):e41-e42. doi: 10.1016/S2213-2600(16)30159-X.
Raoufy MR, Ghafari T, Darooei R, Nazari M, Mahdaviani SA, Eslaminejad AR, Almasnia M, Gharibzadeh S, Mani AR, Hajizadeh S. Classification of Asthma Based on Nonlinear Analysis of Breathing Pattern. PLoS One. 2016 Jan 29;11(1):e0147976. doi: 10.1371/journal.pone.0147976.
Meamar M, Dehpour T, Mazloom R, Sharifi F, Raoufy MR, Dehpour AR, Mani AR. The effect of endotoxin on heart rate dynamics in diabetic rats. Auton Neurosci. 2015 May;189:83-6. doi: 10.1016/j.autneu.2014.12.006.
Shirazi AH, Raoufy MR, Ebadi H, De Rui M, Schiff S, Mazloom R, Hajizadeh S, Gharibzadeh S, Dehpour AR, Amodio P, Jafari GR, Montagnese S, Mani AR. Quantifying memory in complex physiological time-series. PLoS One. 2013 Sep 5;8(9):e72854. doi: 10.1371/journal.pone.0072854.