Brain structural and functional alterations in allergic inflammation - Translational Brain Function & Neuromodulation Lab
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Brain structural and functional alterations in allergic inflammation
Date: 2015-2020
Overview
Psychiatric disorders are prevalent in allergic inflammation, especially asthma, which adversely impact the quality of life and treatment response. Some scholars have speculated that there may be potential immune-brain communication mechanisms in asthma that activate inflammatory response in different brain areas leading to brain structural and functional alterations in association with behavioral changes.
Techniques used in animals include electrophysiological recording (multi-electrode recording of local field potentials (LFP) in conscious animals during behavioral experiments, spike recording and patch clamp recording), brain imaging (MRI), invasive and non-invasive brain stimulation, brain molecular and histological examination. Also, human and clinical techniques include electroencephalography (EEG), brain imaging (MRI and fMRI) and non-invasive brain stimulation. Data analysis is performed with an emphasis on electrical signal processing and image processing.
Selected articles
Dehdar K, Raoufy MR. Brain structural and functional alterations related to anxiety in allergic asthma. Brain Res Bull. 2023 Oct 1;202:110727. doi: 10.1016/j.brainresbull.2023.110727.
Dehdar K, Raoufy MR. Effects of inhaled corticosteroids on brain volumetry, depression and anxiety-like behaviors in a rat model of asthma. Respir Physiol Neurobiol. 2023 Sep;315:104121. doi: 10.1016/j.resp.2023.104121.
Dehdar K, Salimi M, Tabasi F, Dehghan S, Sumiyoshi A, Garousi M, Jamaati H, Javan M, Raoufy MR. Allergen Induces Depression-like Behavior in Association with Altered Prefrontal-hippocampal Circuit in Male Rats. Neuroscience. 2023 Aug 1;524:21-36. doi: 10.1016/j.neuroscience.2023.05.034.
Dehdar K, Mooziri M, Samii Moghaddam A, Salimi M, Nazari M, Dehghan S, Jamaati H, Salimi A, Raoufy MR. Corticosteroid treatment attenuates anxiety and mPFC-amygdala circuit dysfunction in allergic asthma. Life Sci. 2023 Feb 15;315:121373. doi: 10.1016/j.lfs.2023.121373.
Gholami-Mahtaj L, Mooziri M, Bamdad S, Mikaili M, Jamaati H, Raoufy MR. Neural signature of attention impairment in allergic asthma: an ERP study. Int J Neurosci. 2022 Nov 30:1-11. doi: 10.1080/00207454.2022.2151908.
Gholami-Mahtaj L, Mooziri M, Dehdar K, Abdolsamadi M, Salimi M, Raoufy MR. ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety. Sci Rep. 2022 Feb 17;12(1):2731. doi: 10.1038/s41598-022-06748-w.
Gholami-Mahtaj L, Salimi M, Nazari M, Tabasi F, Bamdad S, Dehdar K, Mikaili M, Mahdaviani SA, Salari F, Lookzadeh S, Jamaati H, Salimi A, Raoufy MR. Asthma induces psychiatric impairments in association with default mode and salience networks alteration: A resting-state EEG study. Respir Physiol Neurobiol. 2022 Jun;300:103870. doi: 10.1016/j.resp.2022.103870.
Dehdar K, Salimi M, Raoufy MR. Allergen disrupts amygdala-respiration coupling. Respir Physiol Neurobiol. 2022 Mar;297:103835. doi: 10.1016/j.resp.2021.103835.
Salimi M, Ghazvineh S, Nazari M, Dehdar K, Garousi M, Zare M, Tabasi F, Jamaati H, Salimi A, Barkley V, Mirnajafi-Zadeh J, Raoufy MR. Allergic rhinitis impairs working memory in association with drop of hippocampal - Prefrontal coupling. Brain Res. 2021 May 1;1758:147368. doi: 10.1016/j.brainres.2021.147368.
Dehdar K, Mahdidoust S, Salimi M, Gholami-Mahtaj L, Nazari M, Mohammadi S, Dehghan S, Jamaati H, Khosrowabadi R, Nasiraei-Moghaddam A, Barkley V, Javan M, Mirnajafi-Zadeh J, Sumiyoshi A, Raoufy MR. Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit. Sci Rep. 2019 Dec 20;9(1):19586. doi: 10.1038/s41598-019-55539-3.
Salimi M, Ghazvineh S, Zare M, Parsazadegan T, Dehdar K, Nazari M, Mirnajafi-Zadeh J, Jamaati H, Raoufy MR. Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis. PLoS One. 2019 Sep 11;14(9):e0221978. doi: 10.1371/journal.pone.0221978.
Parsazadegan T, Salimi M, Ghazvineh S, Raoufy MR. Cognitive disorders in allergic rhinitis may be induced by decline of respiration entrained rhythm in the brain. Med Hypotheses. 2018 Dec;121:89-90. doi: 10.1016/j.mehy.2018.09.037.